Orencia - RheumInfo Depending on how much you weigh, you will receive 2 - 4 vials of ORENCIA at a time. Orencia IV should be dosed by patient weight as follows: •Less than 60 kg: 500 mg • 60 to 100 kg: 750 mg • More than 100 kg: 1000 mg. After the initial dose, subsequent IV doses should be given at 2 and 4 weeks, and then every 4 weeks thereafter. The primary endpoint was a 40% improvement in disease activity at PDF Orencia PDF Infusion Orders — Orencia Adults. Following the initial intravenous administration, an intravenous infusion should be given at 2 and 4 weeks after the first . Orencia® (abatacept) dosage will be based on the following guidelines provided by Bristol‐Myers Squibb Body Weight of Patient Dose Number of 250mg (abatacept) Vials < 60 kg 500 mg 2 Your doctor may start your ORENCIA treatment with or without a one-time dose of powder for concentrate for solution for infusion (given to you into a vein, usually in your arm, over a period of . The phase IV clinical study analyzes which people take Orencia and have Weight loss - unintentional. Why I Chose Orencia Infusions vs. Injection for RA Treatment Dosing Limits A. Table 1: Dose of ORENCIAa Body Weight of Patient Dose Number of Vialsb < 60 kg 500mg 2 ≥ 60 kg to ≤ 100 kg 750 mg 3 > 100 kg 1,000mg 4 a Approximating 10 mg/kg. Orencia (Abatacept) - Side Effects, Interactions, Uses ... patients: < 75 kg, 10 mg/kg; > 75 kg, dose as per adult regimen, max 1 g. Subcutaneous (SC): weekly dose of 125 mg regardless of weight and may be initiated with or without an IV loading dose. JHHC SOC Orencia SGM - 09/2021. For RA, many people will get their first dose administered as an IV infusion, then start home injections the next day. Table 2: Dose of ORENCIA for Subcutaneous Administration in Patients 2 Years of Age or Older with JIA . Each vial provides 250 mg of abatacept for administration. Dosing must meet the following: An initial weight-based dose is followed by additional similar doses at 2 and 4 weeks after the first infusion, then every 4 weeks thereafter. old, weight > 75 kg): Refer to adult IV dosing regimen. Each vial provides 250 mg of abatacept for administration. Adult weight-based dosing. 50 kg or more . CVS Caremark Specialty Programs 2969 Mapunapuna Place Honolulu, HI 96819 Phone: 1-808-254-4414 Fax: 1-866-237- 5512 www.caremark.com Patients with severe renal Table 1. Without need for IV loading dose • weight 10 kg to <25 kg: 50 mg weekly • weight 25 kg to <50 kg: 87.5 mg weekly • weight ≥50 kg: 125 mg weekly IV: Administered at 0, 2, and 4 weeks, then every 4 weeks thereafter • weight <75 kg: 10 mg/kg Reconstitute ORENCIA lyophilized powder and administer after dilution [see Dosage and Administration (2.5)] as a 30-minute intravenous infusion utilizing the weight range-based dosing specified in Table 1. • abatacept (Orencia . Intravenous Dosing Regimen. Orencia 500 mg for patients weighing less than 60 kg, Orencia 750 mg for patients weighing 60 to 100 kg, and Orencia 1,000 mg for patients weighing greater than 100 kg (weight-range-based dosing), or • Orencia 30 mg/kg on Days 1 and 15 followed by weight range-based Orencia dosing (i.e., 500 mg for patients weighing less than 60 kg, 750 mg . INTRAVENOUS INFUSION . *Actual day of dosing may vary based on patient scheduling. 5.70.18 Section: Prescription Drugs Effective Date: January 1, 2021 Subsection: Analgesics and Anesthetics Original Policy Date: October 20, 2006 Subject: Orencia Page: 3 of 13 ** applies to Orencia claims adjudicated through the pharmacy benefit. There was a higher proportion of ORENCIA IV patients with at least a 0.30 decrease from baseline in Health Assessment Questionnaire-Disability Index (HAQ-DI) score at Week 24, with an estimated difference for ORENCIA 10 mg/kg (weight range-based dosing as described above) (45.0%) vs. placebo (19.0%) of 26.1 (95% confidence interval: 6.8, 45.5 . INFUSION ORDERS — ORENCIA Date of referral: _____ Patient Name: _____ Date of Birth: _____ ORENCIA IV is approved for children 6 years and older. Body Weight of Patient . Dose: Orencia® (abatacept) dosage per 100 ml Sodium Chloride 0.9% IV to infuse over at least 30 minutes. In an open-label Phase II trial, Orencia was administered by intravenous infusion on Days 1, 15, 29, and every 28 days thereafter to patients with active AS.6 Patients received a fixed dosage of Orencia of approximately 10 mg/kg based on body weight. Number of Vialsa < 60 kg (132 lbs) 500 mg 2 60 to 100 kg (132 - 220 lbs) 750 mg 3 > 100 kg (220 lbs) 1 gram 4 Orencia. ORENCIA lyophilized powder should be reconstituted and administered after dilution [see Dosage and Administration (2.3)] as a 30-minute intravenous infusion utilizing the weight range-based dosing specified in Table 1. the full contents . Intravenous Dosing Regimen ORENCIA IV should be administered as a 30-minute intravenous infusion utilizing the weight range-based dosing specified in Table 1. The recommended dose of ORENCIA for adults with rheumatoid arthritis or psoriatic arthritis is 125 mg abatacept given every week regardless of weight. Immunosuppressive therapies (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, corticosteroids [greater than physiologic doses]) may reduce immune response to dengue vaccine. The IV infusion is only available for children 6 years and older. At Week 24, the ASAS 40 was 13.3% (n Subcutaneous Dosing (Orencia 125 mg Subcutaneous Injection ONLY) • Administer by subcutaneous injection once weekly o May initiate with or without an IV loading dose o If initiated with an IV loading dose, a single weight-based infusion (see above) should be ORENCIA IV has not been studied in children under the age of 6. Use Caution/Monitor. abatacept decreases effects of dengue vaccine by immunosuppressive effects; risk of infection. When body weight less than 60 kg (<132 lbs. 10 kg to less than 25 kg. Pediatric patients with: • body weight less than 75 kg should be administered Orencia at a dose of 10 mg/kg Following the initial intravenous administration, an intravenous infusion should be given at 2 and 4 weeks after the first infusion and every . Study III, IV, V, and VI patients were randomized to receive a dose of ORENCIA based on weight range or placebo for 12 months (Studies III, V, and VI) or 6 months (Study IV). Body weight Dose ORENCIA IV should be administered as a 30-minute intravenous infusion utilizing the weight range-based dosing specified in Table 1. The phase IV clinical study analyzes which people take Orencia and have Weight increased. 87.5 mg . Following the initial IV administration, an 1 IVinfusion should be given at 2 and 4 weeks after the first infusion and every 4 weeks thereafter. Orencia may be considered medically necessary for patients age 18 or older for the treatment of rheumatoid arthritis (RA), or active psoriatic . Quantity Limit (max daily dose) [ NDC Unit ]: x Orencia ClickJect 125 mg autoinjector: 4 syringes per 28 days x Orencia prefilled syringes (50 mg, 87.5 mg, or 125 mg): 4 syringes per 28 days x Orencia 250 mg vials: o Management of Immune -Checkpoint Inhibitor Related Toxicity 2 vials every 14 days for a total for 5 doses ORENCIA SC should be administered weekly at a dose of 125 mg by subcutaneous injection regardless of weight (see section 5.1). initial administration, ORENCIA should be given 2 and 4 weeks after the first infusion, then every 4 weeks thereafter. Subcutaneous Dosing (Orencia 125 mg Subcutaneous Injection ONLY) Administer by subcutaneous injection once weekly o May initiate with or without an IV loading dose o If initiated with an IV loading dose, a single weight-based infusion (see above) Body weight of patient. After that, you will receive an infusion every 4 . Patients switching from ORENCIA IV to ORENCIA SC administration should take their first SC dose instead of their next scheduled IV dose. If a single IV infusion is given to initiate treatment (IV loading dose before SC administration), the first 125 mg abatacept SC should be administered within a day of the IV infusion, followed by the weekly 125 mg . DOSING AND ADMINISTRATION . 500 mg - Patient weight less than 60 kg 750 mg - Patient weight 60-100 kg 1000 mg - Patient weight .
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