Lava Therapeutics' proprietary platform is focused on developing next generation γδ T cell engaging bispecific antibodies to treat cancer. We have achieved preclinical proof-of-concept with LAVA-051 by demonstrating efficacy and safety in a variety of preclinical models. 18 Jan 2022 Safety. Series C financing to fund the advancement of its pipeline and platform. LAVA Therapeutics N.V. is a clinical-stage biotechnology company utilizing its proprietary Gammabody™ platform to develop a portfolio of bispecific gamma delta T cell engagers (gamma delta bsTCEs) for the potential treatment of solid tumors and hematological malignancies. Recent Business and Pipeline Highlights. utrecht, the netherlands & philadelphia, pa, usa i september 17, 2020 i lava therapeutics, a biotech company pioneering the development of bispecific antibodies to engage gamma-delta t cells for cancer therapies, today announced the closing of an oversubscribed $83 million (€71 million) series c financing to fund the advancement of its pipeline … In part 1 (dose escalation) LAVA-051 will be administered via intravenous infusion with dose escalation until an estimated therapeutic dose level has been reached. Under the agreement and using its CHO.RiGHT expression platform, including DirectedLuck Transposase technology for the generation of stable high-titer cell . Submitted on January 25, 2021 . Ms. Garabedian is a seasoned leader with . For the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing activities, BCIQ provides accurate information and context to support profitable and strategic decision making. Draft Registration Statement on Form F-1. The Janux platform enables the rapid identification of TRACTr development candidates due to a modular design that provides multiple opportunities to rapidly develop TRACTr therapeutics. LAVA Therapeutics Expands Management Team with Three Key Appointments. ACHILLES PIPELINE. Pipeline. He has also served as Operational Partner at Gilde Healthcare since December 2017 and as Owner and Chief Executive Officer of Sparring Biologics BV (Holding) and Bioconsult BV since November 2017. Utrecht, The Netherlands and Philadelphia, USA September 17, 2020 - LAVA Therapeutics, a biotech company pioneering the development of bispecific antibodies to engage gamma-delta T cells for cancer therapies, today announced the closing of an oversubscribed $83 million (€71 million) Series C financing to fund the advancement of its pipeline . The SCOOP Rating does not reflect the opinions of anyone associated with IPOScoop.com. Industry: Health Care. LAVA Therapeutics N.V. is a biotechnology company developing a portfolio of bispecific gamma-delta T cell engagers (gamma-delta bsTCEs) for the treatment of solid tumors and . Dutch Phase 1/2a biotech developing gamma-delta T cell therapies for cancer. Utrecht (The Netherlands) and Philadelphia - Gilde Healthcare company Lava Therapeutics announced the closing of an oversubscribed $83 million (€71 million) Series C financing to fund the advancement of its pipeline and platform.The financing was co-led by new investors Novo Ventures and Sanofi Ventures, and included additional new investors Redmile Group LLC, Ysios Capital and BB Pureos . BsAbs come in many formats, ranging from relatively small proteins, merely . I am looking forward to working with the LAVA team to build an organization that brings the exciting γδ T cell engager platform to its fullest potential and rapidly translate it to the . The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. LAVA Therapeutics N.V. is an immuno-oncology company utilizing its proprietary Gammabody™ platform to develop a portfolio of bispecific gamma delta T cell engagers (bsTCEs) for the potential treatment of solid tumors and hematological malignancies. We are creating molecules that are systemically delivered, tissue-directed and locally active. LAVA's pipeline includes four proprietary compounds, and a fifth that is being investigated in combination with Janssen. In part 2 (dose expansion) patients will receive LAVA-051 at the recommended phase 2 dose(s) established in part 1 of the study in disease specific cohorts for MM and/or CLL and/or AML @lava therapeutics 2022 Candidate Antigen Target Indication(s) Discovery Preclinical Phase 1 Phase 2 Phase 3 Milestones LAVA-051 CD1d MM CLL AML •Phase 1 data 2Q 2022 •Phase 2a expansion cohort data 2H 2022 LAVA-1207 PSMA mCRPC •Phase 1 data 2H 2022 •Phase 2a expansion cohort data 1H 2023 We are advancing a pipeline of therapies that . LAVA Therapeutics N.V. is a clinical-stage biotechnology company developing a portfolio of bispecific gamma-delta T cell engagers for the treatment of solid and hematological malignancies. Janux Therapeutics Pipeline. . Report this post. OUR PIPELINE IS DERIVED FROM OUR Immuno TAC ™ PLATFORM. Lava Therapeutics, a Dutch developer of γδ T cell engaging bispecific antibodies to treat cancer, raised €16m in first financing. ProBioGen and LAVA Therapeutics have announced the closing of a second cell line development agreement to support a bispecific gamma-delta T cell engager (TCE) candidate in LAVA's pipeline. . DUBLIN--(BUSINESS WIRE)--Mar 10, 2022--The "Natural Killer (NK) cell therapy - Pipeline Insight, 2022" clinical trials has been added to ResearchAndMarkets.com's offering.. All five drug candidates are in preclinical trials. LAVA Therapeutics N.V. November 9, 2021. Both were granted breakthrough therapy designation to expedite their development and review. The financing was . GM1 Gangliosidosis is a hereditary, progressive disease mostly impacting neurons in the brain and spinal cord, caused by mutations in GLB1, the gene that encodes the beta-galactosidase (GLB) enzyme. Therapeutics have presented preclinical data on multispecific immune cell engagers in recent years. Our novel Gammabody™ platform generates bispecific gamma delta T cell engager therapeutics that activate a unique and relatively abundant effector gamma delta T cell subset called Vγ9Vδ2 (Vgamma9-Vdelta2) T cells. Our lead indications, advanced non-small cell lung cancer and recurrent metastatic melanoma, were selected for their high mutational burden, high level of T cell infiltration and high unmet medical need. The pipeline supports the Company's strategic vision for developing best-in-class treatments by focusing on validated targets . ET. Our lead program, LAVA-051, targets the tumor-specific antigen CD1d, which can be overexpressed in multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and acute myeloid leukemia (AML), among other tumor types. He is focusing on venture and growth capital investments in the biopharmaceutical sector. Lava Therapeutics has launched an initial public offering of25.35M shares at an offering price of$15/share, for gross proceeds of $90.3M.Underwriters have an option to buy additional. Utrecht, The Netherlands and Philadelphia, USA - February 22, 2021 - LAVA Therapeutics B.V., an early clinical-stage biotechnology company focused on applying its expertise in bispecific gamma-delta T cell Get premium features like the IPO pipeline, calendar, enhanced profiles, data screens, valuation metrics, and more. See the complete profile on LinkedIn and discover Amy's . Paul Parren, CEO of the γδ T cell- engaging bispecific company Lava Therapeutics, is watching this space. LAVA Therapeutics Appoints Dr. Kapil Dhingra as Chairman of the Board of Directors in Advance of Lead Program Entering the Clinic . LAVA Therapeutics N.V. is an immuno-oncology company utilizing its proprietary Gammabody™ platform to develop a portfolio of gamma delta bispecific T cell engagers (bsTCEs) for the potential treatment of solid tumors and hematological malignancies. The proceeds of the IPO will be used to drive the development of the company's pipeline of bispecific antibody drugs, which are designed to treat . We are excited to announce the treatment of the first patient in our Phase 1/2a clinical trial of LAVA-1207 with metastatic castration . Pipeline LAVA-051 Our lead program, LAVA-051, is a Gammabody™ that targets CD1d-expressing tumors, including multiple myeloma, chronic lymphocytic leukemia (CLL), and acute myeloid leukemia (AML). The financing was co-led by new investors . The Dutch biotech startup Lava Therapeutics launched onto the Nasdaq stock market last week with an €85.6M ($100.5M) IPO. We believe our proprietary capsid improves the reach of gene therapy to diseases that are not . The publisher's, "Natural Killer (NK) cell therapy - Pipeline Insight, 2022," report provides comprehensive insights about 100+ companies and 185+ pipeline drugs in Natural Killer (NK) cell therapy pipeline . And Molecular Therapeutics is planning on advancing a m ultispecific antibody-like candidate for COVID-19. Berlin, Germany and Utrecht, Netherlands, June 22, 2021: ProBioGen and LAVA Therapeutics N.V. announced the closing of a second cell line development agreement to support a bispecific gamma-delta T cell engager (TCE) candidate in LAVA's pipeline.
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